Thermo Fisher Scientific Topo II Beta Polyclonal Antibody
Rabbit polyclonal antibody targeting human DNA Topoisomerase II Beta (TOP2B). Suitable for IHC and IHC-P applications at 1:100–1:500 dilution. Unconjugated, antigen affinity purified, liquid form. Stored at 4°C; shelf life 1 year. For research use only.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC-P)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 1570 and the C-terminus (residue 1621) of Human DNA Topoisomerase II Beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 50 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Little brown bat and White-tufted-ear marmoset
Target Information
TOP2B (DNA Topoisomerase II Beta) is a protein-coding gene encoding a DNA topoisomerase enzyme that controls and alters DNA topology during transcription.
This nuclear enzyme participates in chromosome condensation, chromatid separation, and relief of torsional stress during DNA transcription and replication.
It catalyzes transient breaks and rejoining of DNA strands, allowing passage and topological changes.
Two forms exist due to gene duplication: beta (chromosome 3) and alpha (chromosome 17).
TOP2B is a target for several anticancer agents, and mutations can lead to drug resistance.
Reduced activity may contribute to ataxia-telangiectasia.
Alternative splicing produces multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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