Thermo Fisher Scientific SYK Polyclonal Antibody
Human SYK 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot과 Immunoprecipitation에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, TBS buffer에 0.1% BSA와 sodium azide가 포함되어 있습니다. 연구용으로만 사용 가능합니다.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 350 and 400 of Human Spleen Tyrosine Kinase (SYK) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, and Pig.
Target Information
Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are potential drug targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer.
Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcεRI) triggering, and phosphorylates downstream adaptor proteins, providing docking sites for signaling pathways such as calcium mobilization, cytoskeleton remodeling, or gene transcription.
Syk binds to receptor assemblies through interactions of its SH2 domains with ITAM motifs phosphorylated by Src-family kinases, which also activate Syk via phosphorylation of its activation loop.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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