Thermo Fisher Scientific IRAK2 Polyclonal Antibody
Human IRAK2 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. 냉장 보관 가능하며 장기 보관 시 -20°C 권장.
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Thermo Fisher Scientific IRAK2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunohistochemistry (IHC) | 20 µg/mL |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to amino acids near the carboxy terminus of human IRAK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153923 |
Product Specific Information
- In Western blot applications, this antibody detects a band at approximately 65 kDa.
- A suggested positive control is HeLa cell lysate.
- PA5-19917 can be used with blocking peptide PEP-0043.
Target Information
IRAK2 (interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor following IL-1 engagement and triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
The pro-inflammatory cytokine IL-1 induces cellular response through two receptor subunits, IL-1RI and IL-1RAcP.
IRAKs mediate activation of NF-κB, a pivotal transcription factor in inflammatory and immune responses.
IRAK2, a novel member of the IRAK/Pelle family, recruits to IL-1R complex subunits after IL-1 binding and leads to NF-κB activation.
Members of the IRAK/Pelle family play a central role in IL-1R and TLR-mediated inflammatory responses to cytokine IL-1 and LPS.
IRAK2 is expressed in a variety of human tissues.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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