Thermo Fisher Scientific AGPAT2 Polyclonal Antibody
Thermo Fisher Scientific의 AGPAT2 Polyclonal Antibody는 인간 AGPAT2 단백질을 인식하는 토끼 유래 다클론 항체입니다. Western blot 및 IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제되었으며, 연구용으로 안정적인 장기 보관이 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human AGPAT2. Recombinant protein control fragment (Product # RP-91098) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2637764 |
Product Specific Information
Immunogen sequence:
YNTKKKFFTS GTVTVQVLEA IPTSGLTAAD VPALVDTCHR AMRTTFLHIS KTPQENGATA GSG
Sequence identity:
Highest antigen sequence identity to the following orthologs:
- Mouse: 63%
- Rat: 63%
Target Information
Lysophospholipid acyltransferases (LPLATs) catalyze the addition of fatty acyl moieties to the glycerol backbone of lysophospholipids.
These enzymes play a crucial role in the synthesis of structural membrane components and are implicated in cellular signaling responses to cytokines, growth factors, and other agonists.
In human mesangial and EL-4 cells, interleukin 1 receptor signaling activates lysophosphatidic acid acyltransferase (LPAAT), generating unsaturated phosphatidic acid species essential for diacylglycerol and interleukin 1 signaling.
LPLATs also contribute to interleukin 2 synthesis signaling via the T cell antigen receptor. Activation of T-cells through anti-CD3 stimulation increases incorporation of polyunsaturated fatty acids into phosphatidylcholine via lysophosphatidylcholine acyltransferase, which is essential for sustained activation and translocation of protein kinase C.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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