Thermo Fisher Scientific ELAC2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ELAC2. Recombinant protein control fragment (Product #RP-92519). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ELAC2,uniProtId:Q9BQ52-1,ncbiNodeId:9606,antigenRange:357-464,antigenLength:826,antigenImageFileName:PA5-54016_ELAC2_Q9BQ52-1_Rabbit.svg,antigenImageFileNamePDP:PA5-54016_ELAC2_Q9BQ52-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2640982

Product Specific Information

Immunogen sequence: WMERFGPDTQ HLVLNENCAS VHNLRSHKIQ TQLNLIHPDI FPLLTSFRCK KEGPTLSVPM VQGECLLKYQ LRPRREWQRD AIITCNPEEF IVEALQLPNF QQSVQEYR

Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 79%.

Target Information

ELAC2 encodes a protein that has a C-terminal domain with tRNA 3 processing endoribonuclease activity, which catalyzes the removal of the 3` trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.