Thermo Fisher Scientific ELAC2 Polyclonal Antibody
Human ELAC2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 안정성을 제공. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ELAC2. Recombinant protein control fragment (Product #RP-92519). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640982 |
Product Specific Information
Immunogen sequence:
WMERFGPDTQ HLVLNENCAS VHNLRSHKIQ TQLNLIHPDI FPLLTSFRCK KEGPTLSVPM VQGECLLKYQ LRPRREWQRD AIITCNPEEF IVEALQLPNF QQSVQEYR
Antigen sequence identity:
- Mouse: 80%
- Rat: 79%
Target Information
ELAC2 encodes a protein that has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3′ trailer from precursor tRNAs. The protein interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (FAST-1). Reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene are associated with increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been identified.
Note: For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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