Thermo Fisher Scientific ABCG8 Polyclonal Antibody
Human ABCG8 단백질에 특이적인 Rabbit Polyclonal 항체로, IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 4°C 단기 보관 및 -20°C 장기 보관 권장. ABCG8 단백질 연구용으로 적합.
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Applications
Tested Application
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ABCG8. Recombinant protein control fragment (Product # RP-91216) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2637543 |
Product Specific Information
Immunogen sequence:
HMVQYFTAIG YPCPRYSNPA DFYVDLTSID RRSREQELAT REKAQSLAAL FLEKVRDLDD FLWKAETKDL DEDTCVESSV TPLDTNCLPS PTKMPGAVQQ FTTLIRRQIS NDFRDLP
- Highest antigen sequence identity to the following orthologs:
- Mouse: 70%
- Rat: 74%
Target Information
ATP-binding cassette (ABC) transporter genes are involved in regulating dietary cholesterol retention.
ABCG8, highly expressed in the liver and intestine, cooperates with ABCG5 to limit intestinal absorption and promote biliary excretion of sterols.
Mutations in this transporter can cause sterol accumulation, leading to atherosclerosis or sitosterolemia—a rare autosomal recessive disorder characterized by hyperabsorption of sterols and impaired biliary excretion.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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