Thermo Fisher Scientific SIRT1 Monoclonal Antibody (19A7AB4)
SIRT1 단백질을 인식하는 Thermo Fisher의 mouse monoclonal 항체로, Western blot, ICC/IF, ELISA에 사용 가능. 재조합 인간 SIRT1,2,3,4로부터 유래된 항원 사용. 액상 형태, 4°C 보관, 연구용 전용 시약.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 2 publications |
| Immunocytochemistry (ICC/IF) | 0.5 µg/mL | - |
| ELISA | Assay-dependent | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 19A7AB4 |
| Immunogen | Recombinant human SIRT1, 2, 3, 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | 4°C, do not freeze |
| RRID | AB_2535904 |
Product Specific Information
The antibody was produced in vitro using hybridomas grown in serum-free medium, and purified by biochemical fractionation.
Target Information
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation to intracellular energetics and coordinates several cellular processes including cell cycle, DNA damage response, metabolism, apoptosis, and autophagy.
SIRT1 modulates chromatin function through histone deacetylation and influences histone and DNA methylation, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and mediates inhibitory effects under low nutrient conditions involving AMPK and NAMPT.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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