Thermo Fisher Scientific USP3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse

Target Information

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity.

Deubiquitination, catalyzed by deubiquitinating enzymes, adds another level of ubiquitin regulation. These enzymes fall into four distinct families:

1. Ubiquitin C-terminal hydrolases
2. Ubiquitin-specific processing proteases (USPs)
3. OTU-domain ubiquitin-aldehyde-binding proteins
4. Jab1/Pad1/MPN-domain-containing metallo-enzymes

Among these, USPs are the most widespread and conserved deubiquitinating enzymes across evolution. They release ubiquitin from conjugated proteins and possess conserved catalytic domains with Cys and His boxes. Their N- and C-terminal extensions contribute to substrate recognition, subcellular localization, and protein–protein interactions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.