Thermo Fisher Scientific ARHGEF11 Polyclonal Antibody
ARHGEF11 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관됩니다. 인간 시료 반응성이 있으며 연구용으로만 사용 가능합니다.
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Applications
Tested Application
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ARHGEF11. Recombinant protein control fragment (Product # RP-89159) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2638162 |
Product Specific Information
Immunogen sequence:
PGHTMETQAA QEPEDDLTPT PSVISVTSHP WDPGSPGQAP PGGEGDNTQL AGLEGERPEQ EDMGLCSLEH LPPRTRNSGI WESPELDRNL AEDASSTEAA GGYKVVRKAE VAGSKVVPAL P
Highest antigen sequence identity to the following orthologs:
- Mouse: 70%
- Rat: 62%
Target Information
ARHGEF11 is a 1527 amino acid protein with tandem dbl homology and pleckstrin homology domains, PDZ domain, two proline-rich sequences, and a regulatory G protein-signaling (RGS) sequence. It acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase, but not for RAC1 or CDC42, and as a GTPase-activating protein (GAP) for GNA12 and GNA13.
It forms a complex with G proteins and stimulates neurite retraction through Rho-dependent signaling. ARHGEF11 increases glutamate transport fourfold, interacts with EAAT4, and modulates uptake activity and perisynaptic distribution at glutamatergic synapses.
Overexpression induces actin cytoskeleton reorganization, membrane ruffling, and filopodia formation. It is ubiquitously expressed in brain, lung, liver, kidney, and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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