Thermo Fisher Scientific UCH37 Polyclonal Antibody
Human UCH37 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 등 다양한 응용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 암 관련 단백질 연구 및 TGFβ 신호 조절 연구에 적합.
- 판매단위
- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human UCH37. Recombinant protein control fragment (Product #RP-88752). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2649224 |
Product Specific Information
- Immunogen sequence:
CTHQDVHLGE TLSEFKEFSQ SFDAAMKGLA LSNSDVIRQV HNSFARQQMF EFDTKT - Highest antigen sequence identity:
- Mouse: 100%
- Rat: 100%
Target Information
UCH-L5 (ubiquitin carboxyl-terminal hydrolase isozyme L5), also known as UCH37, is a 329 amino acid protein that edits polyubiquitinated protein substrates. UCH-L5 may rescue ubiquitinated proteins, including oncogenic proteins, from proteasomal degradation, potentially influencing tumor growth.
Through associations with Smad7, UCH-L5 can upregulate TGFβ-dependent gene expression by deubiquitinating and stabilizing TGFβ RI. Overexpression of UCH-L5 and other deubiquitinating enzymes has been observed in many cancer cell lines, making them potential targets for cancer therapy.
Four isoforms of UCH-L5 exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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