Thermo Fisher Scientific PKC beta-2 Recombinant Rabbit Monoclonal Antibody (ST48-06)
PKC beta-2 단백질을 인식하는 Thermo Fisher의 재조합 토끼 단클론 항체로, WB, IHC, ICC, Flow Cytometry에 적합합니다. HEK293 세포에서 발현된 IgG 형식이며, 높은 특이성과 재현성을 제공합니다. 단기 4°C, 장기 -20°C 보관 권장.
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ST48-06 |
| Immunogen | Synthetic peptide within Human PKC beta 2 (aa 615–660) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809450 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
The PKC family of serine/threonine kinases, including PRKCB2 (PKC beta II), is activated by intracellular signal transduction pathways. In humans, at least 12 PKC isoforms have been identified, differing in structure, localization, and substrate specificity.
Conventional PKC isoforms (α, βI, βII, γ) are Ca²⁺- and phospholipid-dependent. PKC proteins phosphorylate diverse targets and are involved in multiple signaling pathways, serving as receptors for phorbol esters (tumor promoters).
PKC beta-2 is implicated in various cellular processes such as:
- B cell activation
- Apoptosis induction
- Endothelial cell proliferation
- Intestinal sugar absorption
Mouse studies suggest roles in neuronal function and stress-related behavior regulation. Alternative splicing produces distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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