Thermo Fisher Scientific Human ICAM-1 (CD54) Recombinant Protein
Human ICAM-1 (CD54) 재조합 단백질로, E. coli 발현 시스템에서 생산된 N-말단 His-tag 단백질입니다. 면역학적 분석의 양성 대조군으로 사용 가능하며, 고순도(>95%)로 정제되어 있습니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- RP75641
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Assay-dependent
Control (Ctrl)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | E. coli |
| Amino Acid Sequence | Amino acids Gln28–Val482 containing an N-terminal His-tag |
| Tag | His-tag |
| Class | Recombinant |
| Type | Protein |
| Purity | >95%, by SDS-PAGE under reducing conditions |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.165 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS/20mM Tris HCl, pH 8, with 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Product Specific Information
RP-75641 contains purified recombinant human ICAM-1 protein with an N-terminal hexahistidine tag.
RP-75641 may be used as a positive control in many immunological assays.
Target Information
ICAM-1 (CD54) is an 85–110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region, and a cytoplasmic domain.
ICAM-1 has seven potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102).
It binds to integrins of type CD11a/CD18 (LFA-1) or CD11b/CD18 (Mac-1) and serves as a receptor for Rhinovirus.
ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells, and neutrophils, with levels increasing upon inflammation.
It is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in plasma and elevated in patients with various inflammatory syndromes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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