Thermo Fisher Scientific BDNF Polyclonal Antibody
Thermo Fisher Scientific의 BDNF Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하는 토끼 유래 항체입니다. WB, IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능하며, 뇌신경 성장인자 연구에 적합합니다. 동결건조 형태로 제공되며, -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent | - |
| Immunocytochemistry (ICC/IF) | 1:200 | - |
| ELISA | 1:1,000–1:5,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (HSDPARRGEL) corresponding to human BDNF (aa 129–138) conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1070635 |
Product Specific Information
Reconstitute in 100 µL of sterile water and centrifuge to remove any insoluble material. After reconstitution, store aliquots at -20°C for higher stability or at 4°C with an antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
Target Information
BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. It is synthesized as pre-proBDNF, processed to proBDNF, and further cleaved to the mature 14 kDa protein. Both pro-BDNF and mature BDNF are biologically active and secreted in synaptic vesicles.
BDNF is widely expressed in the central nervous system and acts through the TrkB receptor and the lower-affinity receptor p75-NTR. It promotes neuronal survival, differentiation, and plays a key role in memory formation and synaptic plasticity.
Reduced expression of BDNF has been observed in Alzheimer’s and Huntington’s disease, and it is also implicated in stress response and mood disorder regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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