
Thermo Fisher Scientific TIM3/HAVCR2/CD366 (Effector T-Cell Marker) Monoclonal Antibody (TIM3/2399)
인간 TIM3/HAVCR2/CD366 항원을 인식하는 마우스 단클론 항체입니다. Effector T 세포 표지자로 IHC(P) 및 IHC(PFA) 실험에 적합합니다. Protein A/G로 정제되었으며, PBS 완충액에 보관됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- 84868-MSM1-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TIM3/HAVCR2/CD366 (Effector T-Cell Marker) Monoclonal Antibody (TIM3/2399)
Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TIM3/2399 |
| Immunogen | Recombinant fragment of human TIM3 protein (around aa 22–202) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid Type-I Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+ Th1 and CD8+ Tc1 cells.
It consists of an IgV-like domain, a mucin-like extracellular domain, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
TIM3 is involved in macrophage activation, autoimmune disease induction, and regulation of Th1-mediated immune responses, contributing to immune tolerance.
It has pathological significance in experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease, where it enhances disease severity in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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