Thermo Fisher Scientific TIM3/HAVCR2/ CD366 (Effector T-Cell Marker) Monoclonal Antibody (TIM3/4025)
Effector T-cell marker TIM3/HAVCR2/CD366에 특이적인 단클론 항체로, 인간 시료에 반응합니다. Western blot, IHC 등 다양한 응용에 적합하며, PBS 버퍼에 안정적으로 보관됩니다. 단백질 A/G로 정제된 고품질 항체로 연구용에 최적화되어 있습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TIM3/4025 |
| Immunogen | Recombinant fragment of human TIM3 protein (around aa 22–202) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid long, type-1 Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4⁺ Th1 and CD8⁺ Tc1 cells.
TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
It is involved in macrophage activation and induction of autoimmune diseases.
TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates immune tolerance.
Pathological significance of TIM3 is associated with experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease, and enhances the severity of EAE in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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