Thermo Fisher Scientific TNFRSF18 Monoclonal Antibody (OTI4A9), TrueMAB
Human TNFRSF18 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 Flow cytometry에 사용 가능. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol buffer에 보관. 연구용 전용 제품으로 T-cell 활성화 관련 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4A9 |
| Immunogen | Human recombinant protein fragment (aa 26–162 of human TNFRSF18) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as GITR or AITR, is a protein encoded by the TNFRSF18 gene in humans (mapped to 1p36.33). This receptor belongs to the TNF-receptor superfamily and shows increased expression upon T-cell activation. It plays a key role in maintaining immunological self-tolerance through CD25⁺CD4⁺ regulatory T cells. Mouse knockout studies suggest its involvement in regulating CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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