Thermo Fisher Scientific PCDHGC5 Monoclonal Antibody (OTI2E1), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

This gene belongs to the protocadherin gamma gene cluster, one of three related clusters on chromosome 5. These clusters have an immunoglobulin-like organization, suggesting a novel regulatory mechanism.
The gamma cluster includes 22 genes divided into three subfamilies:

• Subfamily A: 12 genes
• Subfamily B: 7 genes and 2 pseudogenes
• Subfamily C: 3 genes

Each variable region exon encodes the extracellular region (6 cadherin ectodomains and a transmembrane region), followed by a constant region encoding the common cytoplasmic domain. These neural cadherin-like cell adhesion proteins likely play key roles in establishing specific cell-cell connections in the brain. Alternative splicing has been observed for the gamma cluster genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.