Thermo Fisher Scientific Periostin Monoclonal Antibody (OTI2F7), TrueMAB
인간 Periostin 단백질을 인식하는 마우스 단일클론 항체. Western blot 및 IHC(P) 검증 완료. 비결합형 액상 형태로 1 mg/mL 농도 제공. 골형성 관련 연구 및 암 조직 내 발현 분석에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 538–781 of human POSTN produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Periostin (PN), also known as osteoblast-specific factor 2 (OSF-2), is a disulfide-linked protein originally isolated as an osteoblast-specific factor. It is a secreted protein that binds heparin and functions as a ligand for α(V)β(3) and α(V)β(5) integrins.
In preosteoblasts, Periostin acts as a cell adhesion molecule, playing a role in osteoblast recruitment, spreading, and attachment. It is mainly detected in the lower gastrointestinal tract, aorta, stomach, placenta, uterus, and breast tissues, but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer.
Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGF-β1). The protein contains a signal sequence, a cysteine-rich domain, four fasciclin-like repeated domains, and a C-terminal domain.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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