Thermo Fisher Scientific Calsequestrin 2 Polyclonal Antibody
Calsequestrin 2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot, IHC, ICC/IF에 사용 가능. 고순도 친화 크로마토그래피 정제, PBS/glycerol 저장, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CASQ2 (Accession O14958), corresponding to amino acid residues A272–F322 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852344 |
Product Specific Information
Antibody detects endogenous levels of total CASQ2.
Target Information
Calsequestrin (CASQ) is a Ca²⁺-binding protein present primarily in the junctional sarcoplasmic reticulum of skeletal and cardiac muscle. The cardiac form (CASQ2) is encoded by a separate gene. The primary role of CASQ2 is buffering of sarcoplasmic reticulum Ca²⁺ ions, and it also regulates the open probability of ryanodine receptor 2 (RyR2). Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia (CPVT2), characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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