Thermo Fisher Scientific ICAM3 Polyclonal Antibody
ICAM3 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 및 Mouse 시료에 반응합니다. Western blot, IHC(P), ICC/IF 등 다양한 응용에 적합하며, Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관하며 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ICAM3 (Accession P32942), corresponding to amino acid residues G383–L433 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852343 |
Product Specific Information
Antibody detects endogenous levels of total ICAM3.
Target Information
CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin.
ICAM-3 functions as an adhesive molecule mediating contact between T cells and antigen-presenting cells, regulates the affinity of LFA-1 for ICAM-1, and induces T cell activation and proliferation.
It plays an essential role in the initiation of the immune response on both T cells and antigen-presenting cells and interacts with CD209 (DC-SIGN), a C-type lectin of dendritic cells and macrophages, facilitating communication between dendritic cells and granulocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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