Thermo Fisher Scientific NOTCH3 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Positive test controls include 293T cells.
Target localization: Cell membrane, Nucleus, Single-pass type I membrane protein.

Immunogen sequence:
PPEELLRSSA DFLQRLSAIL RTSLRFRLDA HGQAMVFPYH RPSPGSEPRA RRELAPEVIG SVVMLEIDNR LCLQSPENDH CFPDAQSAAD YLGALSAVER LDFPYPLRDV RGEPLEPPEPS

Target Information

NOTCH3 is the third discovered human homologue of the Drosophila melanogaster type I membrane protein notch.
In Drosophila, notch interaction with its cell-bound ligands delta and serrate establishes an intercellular signalling pathway that plays a key role in neural development.
Human homologues of these ligands have also been identified.
NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination.
Mutations in NOTCH3 are known to cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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