Thermo Fisher Scientific Nkx2.1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Nkx2.1, validated for WB and ELISA. Recognizes nuclear protein involved in thyroid and lung development. Supplied as liquid, 0.55 mg/mL, affinity purified, stored at -20°C. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 20–110 of human NKX2-1 (NP_003308.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.55 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914426 |
Product Specific Information
- Positive test controls include: NCI-H460
- Subcellular location: Nucleus
- Immunogen sequence:
LEESYKKVGM EGGGLGAPLA AYRQGQAAPP TAAMQQHAVG HHGAVTAAYH MTAAGVPQLS HSAVGGYCNG NLGNMSELPP YQDTMRNSAS G
Target Information
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes, and also controls genes involved in morphogenesis.
Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be linked to thyroid cancer. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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