Thermo Fisher Scientific Phospho-FOXO4 (Thr455) Polyclonal Antibody
FOXO4 단백질 Thr455 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 사용 가능. 액상 형태로 제공되며 -20°C에서 보관. 인슐린/IGF1 신호전달 관련 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human AFX1 around the phosphorylation site of Thr455 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817252 |
Target Information
FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome. It is also known as AFX1 or MLLT7 (Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Translocated To, 7)).
FOXO4 belongs to the O class of forkhead/winged helix family of transcription factors along with FOXO1, FOXO3, and FOXO6.
It is abundantly expressed in skeletal muscle and adipose tissue, binds to the Insulin Responsive Element (IRE), and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1.
Phosphorylation by Akt on specific Ser/Thr residues mediates binding of FOXO4 to 14-3-3 and promotes its nuclear export.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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