Thermo Fisher Scientific Mel-18 Polyclonal Antibody
Mel-18 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western Blot 및 Immunoprecipitation에 사용 가능. 농도 1 mg/mL, 액상 형태이며 4°C에서 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 125 and 175 of human DNA-binding Protein Mel-18 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
The protein encoded by this gene contains a RING finger motif and is similar to polycomb group (PcG) gene products. PcG proteins form complexes via protein-protein interactions and maintain transcriptional repression of genes involved in embryogenesis, cell cycle, and tumorigenesis.
Mel-18 acts as a negative regulator of transcription and exhibits tumor suppressor activity. Its expression is detected in various tumor cells but is limited in neural organs in normal tissues.
Knockout studies in mice suggest that Mel-18 negatively regulates cytokine, chemokine, and chemokine receptor expression, playing an important role in lymphocyte differentiation, migration, and immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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