Thermo Fisher Scientific PDE6D Polyclonal Antibody
PDE6D 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, ICC/IF, IHC(F) 등에 사용 가능. Bovine, Human, Sheep 시료에 반응하며, 고순도 항원 친화 크로마토그래피로 정제됨. 시각계 신호전달 관련 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2.0 µg/mL | - |
| Immunohistochemistry (Frozen) (IHC (F)) | 1.0 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 1:10–1:200 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Human, Sheep |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic Peptides: M(1) S A K D E R A R (D/E) I L R G F K(16) C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2283611 |
Product Specific Information
PA1-726 detects PrBP/delta from bovine, human, and sheep samples.
It has been successfully used in Western blot, ICC/IF, and immunohistochemistry procedures.
By Western blot, this antibody detects a 17 kDa protein representing PrBP/delta from bovine and sheep retinal/optic nerve extracts as well as HeLa cell lysate.
Immunohistochemical staining of PrBP/delta in bovine retinal cross-sections using PA1-726 results in staining of retinal outer segments.
PA1-726 immunizing peptides correspond to amino acid residues 1–16 from mouse and human PrBP/delta.
This peptide (Cat. # PEP-203) is available for use in neutralization and control experiments.
Target Information
PrBP/delta, previously known as PDE6/delta, is the effector enzyme in the G protein-mediated signal transduction cascade in the visual system.
There are five different subunits consisting of rod and cone specific catalytic subunits: alpha (Cone), alpha (Rod), beta (Rod), the inhibitory subunit gamma, and subunit delta of unknown function.
Subunit delta likely interacts with many other proteins besides the PDE6 family.
PRBP/delta has been implicated in the transport and membrane targeting of prenylated proteins (including PDE6) from their site of synthesis in the inner segment to their final destination in the outer segment of rods and cones (Norton et al., 2005).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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