Thermo Fisher Scientific Phospho-STAT5 beta (Ser731) Polyclonal Antibody
STAT5B의 Ser731 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot, IHC, ICC/IF에 사용 가능. 인간, 생쥐, 랫트 반응성. 고순도 정제 및 안정한 PBS/glycerol 포뮬레이션. 연구용으로만 사용 가능.
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- PA5104920
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human STAT5B (Accession P51692), corresponding to amino acid residues around phosphorylated Ser731 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816393 |
Product Specific Information
Antibody detects endogenous levels of STAT5B only when phosphorylated at Serine 731.
Target Information
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases and then form homo- or heterodimers that translocate to the cell nucleus, where they act as transcription activators.
This protein mediates signal transduction triggered by ligands such as IL2, IL4, CSF1, and various growth hormones. It is involved in biological processes including TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression.
The STAT5B gene can fuse with the retinoic acid receptor-alpha (RARA) gene in a subset of acute promyelocytic leukemias (APLL). Dysregulation of its signaling pathways may contribute to APLL pathogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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