Thermo Fisher Scientific Cholera Toxin beta Monoclonal Antibody (3D11)

Applications

Tested Dilution

Publications

ELISA (ELISA)

1:1,000,000

-

Product Specifications

Species Reactivity

Bacteria

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

3D11

Immunogen

Purified beta subunit of cholera toxin.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3.1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_558404

Product Specific Information

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Cholera toxin (sometimes abbreviated to CTX, Ctx, or CT) is a protein complex secreted by the bacterium Vibrio cholerae. CTX is the causative agent of cholera infection. The alpha subunit contains two chains, A1 and A2, linked by a disulfide bridge. The alpha subunit activates the adenylate cyclase enzyme in cells of the intestinal mucosa leading to increased levels of intracellular cAMP. The beta subunit of cholera toxin binds to a GM1-ganglioside receptor which is widely accepted to initiate toxin action by triggering uptake and delivery of the toxin alpha subunit into cells. The holotoxin consists of a pentameric ring of beta subunits whose central pore is occupied by the alpha subunit.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.