Thermo Fisher Scientific CXCR3 (CD183) Monoclonal Antibody (1C6)
CXCR3 (CD183) 단백질을 인식하는 Mouse IgG1 단클론 항체로, WB, IHC, Flow Cytometry에 적합. 인간, 마우스, 랫트 반응성. 액상 형태로 0.5 mg/mL 농도, Protein A 정제. 염증 관련 T세포 연구용에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Flow Cytometry (Flow) | 0.5–5 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1C6 |
| Immunogen | A 37aa synthetic peptide corresponding to the N-terminus of human CXCR3 conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Transfected CXCR3 Cells
- Cellular Location: Cell Membrane
Target Information
This gene encodes a G protein-coupled receptor with selectivity for three chemokines: IP10 (interferon-γ-inducible 10 kDa protein), Mig (monokine induced by interferon-γ), and I-TAC (interferon-inducible T cell α-chemoattractant).
These chemokines belong to the CXC subfamily, characterized by a single amino acid separating the first two of four conserved cysteine residues. Binding of chemokines to CXCR3 induces leukocyte traffic responses such as integrin activation, cytoskeletal changes, and chemotactic migration.
Inhibition by Bordetella pertussis toxin suggests coupling with Gi-class G proteins. The receptor undergoes phosphorylation-dependent internalization upon activation, followed by recycling after dephosphorylation. CXCR3 is highly expressed in effector/memory T cells and inflamed tissues, mediating recruitment of inflammatory cells.
Thus, CXCR3 is a potential therapeutic target for inflammatory disease modulation. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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