Thermo Fisher Scientific Phospho-p53 (Ser15) Recombinant Rabbit Monoclonal Antibody (P53S15-1C11)
p53 단백질의 Ser15 인산화 형태를 특이적으로 인식하는 재조합 토끼 단클론 항체. Western blot 및 유세포분석에 적합하며, 인간과 마우스 시료 모두 반응. Protein A/G로 정제된 액상 항체로, -20°C에서 보관.
- 카탈로그번호
- MA537236
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Assay-dependent
Flow Cytometry (Flow)
- 1–1,000 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | P53S15-1C11 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Ser15 of human phospho p53 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 50% glycerol, 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897170 |
Additional Formats
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation.
p53 activation leads to transcription of genes such as p21waf1, regulating G1 or G2/M arrest. Structurally, p53 contains an N-terminal transactivation domain, a central DNA-binding domain, an oligomerization domain, and a C-terminal regulatory domain.
Phosphorylation at Ser15 is critical for p53 activation and stabilization. p53 plays a key role in blocking proliferation of damaged cells and functions as an anticancer factor. Mutations in TP53 are common in human cancers and result in loss of tumor suppressor activity. Germline mutations can also cause cancer-prone syndromes such as Li-Fraumeni syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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