Thermo Fisher Scientific ATG2B Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ATG2B. Recombinant protein control fragment (Product #RP-88911). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ATG2B,uniProtId:Q96BY7-1,ncbiNodeId:9606,antigenRange:1667-1806,antigenLength:2078,antigenImageFileName:PA5-51576_ATG2B_Q96BY7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-51576_ATG2B_Q96BY7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2638331

Product Specific Information

Immunogen sequence: CSKEMPRKAH SNMLTVKALH VCPESGRSPQ ECCLRVSLMP LRLNIDQDAL FFLKDFFTSL SAEVELQMTP DPEVKKSPGA DVTCSLPRHL STSKEPNLVI SFSGPKQPSQ NDSANSVEVV NGMEEKNFSA EEASFRDQPV

Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 86%.

Target Information

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. Another member of the autophagy family of proteins is ATG2B, one of two homologs of ATG2 that is essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. Relatively high rates of ATG2B mutations were observed in gastric and colorectal carcinomas, suggesting that deregulating the autophagy process may contribute to cancer development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.