Thermo Fisher Scientific RFWD3 Polyclonal Antibody
RFWD3 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IP에 적합합니다. 인간 반응성이며, DNA 손상 복구 연구에 활용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태, 4°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 724–774 of Human ring finger and WD repeat domain 3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Pig, Orangutan, Monkey, Gorilla, and Chimpanzee
Target Information
E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage. Plays a key role in RPA-mediated DNA damage signaling and repair.
Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2, RPA3) and RAD51 at stalled replication forks, promoting homologous recombination.
Also mediates ubiquitination of p53/TP53, acts as a positive regulator of p53 stability, and regulates the G1/S DNA damage checkpoint.
In response to ionizing radiation, interacts with MDM2 and enhances p53 ubiquitination.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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