Thermo Fisher Scientific c-Raf Monoclonal Antibody (4G4)
c-Raf 단백질을 인식하는 Mouse monoclonal antibody로, Human, Rat, Non-human primate에 반응합니다. Western blot, IHC, Flow cytometry, ELISA에 사용 가능하며, 단백질 G로 정제된 액상 형태입니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 | - |
| Flow Cytometry (Flow) | 1:200–1:400 | - |
| ELISA | 1:10,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate, Rat |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G4 |
| Immunogen | Purified recombinant fragment of human RAF1 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538633 |
Product Specific Information
MA5-17162 targets RAF1 in indirect ELISA, FACS, IHC, and WB applications and shows reactivity with Human samples.
The immunogen is a purified recombinant fragment of human RAF1 expressed in E. coli.
Target Information
Raf-1 (c-Raf) is a MAP kinase kinase kinase (MAP3K) functioning downstream of Ras family GTPases. Once activated, Raf-1 phosphorylates MEK1 and MEK2, which subsequently activate ERK1 and ERK2. Activated ERKs regulate gene expression involved in cell cycle, apoptosis, differentiation, and migration.
Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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