Thermo Fisher Scientific SHP2 Monoclonal Antibody (6D9)
Human SHP2(PTPN11) 단백질을 인식하는 Mouse monoclonal antibody(6D9)로, WB, IHC, ICC, Flow, ELISA에 사용 가능. Protein G 정제, 1 mg/mL 농도, PBS buffer에 0.05% sodium azide 포함. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6D9 |
| Immunogen | Purified recombinant fragment of human PTPN11 (amino acids 263–329) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538631 |
Product Specific Information
MA5-17160 targets PTPN11 in indirect ELISA, FACS, ICC, IHC, IF, and WB applications, showing reactivity with human samples.
The immunogen is a purified recombinant fragment of human PTPN11 (amino acids 263–329) expressed in E. coli.
MA5-17160 detects PTPN11, which has a predicted molecular weight of approximately 68.4 kDa.
Target Information
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate various cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
This PTP contains two tandem Src homology-2 domains, functioning as phospho-tyrosine binding domains mediating substrate interactions. It is widely expressed in most tissues and plays a regulatory role in cell signaling events related to mitogenic activation, metabolic control, transcription regulation, and cell migration.
Mutations in this gene are associated with Noonan syndrome and acute myeloid leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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