Thermo Fisher Scientific Phospho-ATF2 (Ser472) Polyclonal Antibody
Phospho-ATF2 (Ser472)을 인식하는 Rabbit Polyclonal Antibody로, 인간 시료에 반응합니다. IHC(P)에서 1:50–1:100 희석비로 사용 가능하며, positive control로 human brain tissue가 권장됩니다. Affinity chromatography로 정제된 액상 항체입니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of Serine 472 (E-A-V(p)-A-T) derived from Human ATF-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2554139 |
Product Specific Information
- A suggested positive control for IHC is human brain tissue.
Target Information
The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins.
ATF-2 interacts with various viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways.
Cellular stress such as genotoxic agents, inflammatory cytokines, and UV irradiation stimulate ATF-2 transcriptional activity.
Activation occurs via phosphorylation of Thr69 and Thr71 by SAPK and p38 MAPK both in vitro and in transfected cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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