Thermo Fisher Scientific Phospho-ATF2 (Ser44, Ser62) Polyclonal Antibody
ATF2 단백질의 Ser44 및 Ser62 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(Paraffin) 분석에 적합. Human, Mouse, Rat 시료에 반응하며, 고순도 Affinity chromatography 정제. 연구용으로만 사용 가능.
- 카탈로그번호
- PA537531
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of serine 62 or 44 (N-D-S(p)-V-I) derived from Human ATF2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554140 |
Product Specific Information
- Suggested positive control for Western blot: MDA231 cells
- Suggested positive control for IHC: Human breast carcinoma
Target Information
ATF-2 (also called CRE-BP1) is a transcription factor that binds to both AP-1 and CRE DNA response elements and belongs to the ATF/CREB family of leucine zipper proteins. It interacts with various viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways. Cellular stress, including genotoxic agents, inflammatory cytokines, and UV irradiation, activates ATF-2 transcriptional activity through phosphorylation at Thr69 and Thr71. Both SAPK and p38 MAPK phosphorylate ATF-2 at these sites in vitro and in transfected cells.
주의사항
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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