Thermo Fisher Scientific beta Tubulin Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Positive Samples: HeLa
• Cellular Location: Cytoplasm, cytoskeleton

Immunogen sequence:
SDLQLERISV YYNEASSHKY VPRAILVDLE PGTMDSVRSG AFGHLFRPDN FIFGQSGAGN NWAKGHYTEG AELVDSVLDV VRKECENCDC LQGFQLTHSL GGGTGSGMGT LLISKVREEY PDRIMNTFSV VPSPKVSDTV VEPYNATLSI HQLVENTDET YCIDNEALYD ICFRTLKLAT PTYGDLNHLV SATMSGVTTS LRFPGQLNAD LRKLAVNMVP F

Target Information

Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Beta-III tubulin is primarily expressed in neurons and may be involved in neurogenesis, axon guidance, and maintenance. Mutations in the beta tubulin gene cause congenital fibrosis of the extraocular muscles type 3. Beta-III tubulin is also detected in Sertoli cells and transiently in non-neuronal embryonic tissues. Glutamate residues at the C-terminus of beta III tubulin can be glutamylated, though the function is unclear. Tubulin is phosphorylated on Ser-172 by CDK1 during cell cycle progression, inhibiting incorporation into microtubules.

Microtubules, the major cytoskeletal elements found in all eukaryotic cells, consist of Tubulin dimers (alpha and beta subunits, ~55 kDa each). They play key roles in:

• Chromosome segregation in mitosis
• Intracellular transport
• Ciliary and flagellar bending
• Structural support of the cytoskeleton

Because beta-tubulin is ubiquitously expressed, it is often used as a loading control in protein detection assays such as Western blotting.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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