Thermo Fisher Scientific Cytokeratin 16 (KRT16) Monoclonal Antibody (KRT16, 1714)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 0.1–0.2 µg/mL
• Publications: [References not provided]

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
• For formalin-fixed tissues: Heat tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, then cool at room temperature for 20 min.

Target Information

KRT16 is a member of the keratin gene family. Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most type I cytokeratins consist of acidic proteins arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12–q21.
KRT16 is coexpressed with keratin 14 in epithelial tissues such as esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma, and unilateral palmoplantar verrucous nevus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.