Thermo Fisher Scientific KDM5B Monoclonal Antibody (7H3D7)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 1 publication 1 publication

Flow Cytometry (Flow)

1:200-1:400

-

ELISA (ELISA)

1:10,000

-

Product Specifications

Species Reactivity

Human

Published species

Not Applicable

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

7H3D7

Immunogen

Purified recombinant fragment of human KDM5B (AA: 231-319) expressed in E. coli. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:KDM5B,uniProtId:Q9UGL1-1,ncbiNodeId:9606,antigenRange:231-319,antigenLength:1544,antigenImageFileName:MA5-31785_KDM5B_Q9UGL1-1_House_mouse.svg,antigenImageFileNamePDP:MA5-31785_KDM5B_Q9UGL1-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2787408

Product Specific Information

MA5-31785 has been tested in indirect ELISA.

Target Information

KDM5B is a histone demethylase that demethylates Lys-4 of histone H3, thereby playing a central role in histone code. It does not demethylate histone H3 Lys-9 or H3 Lys-27. KDM5B demethylates trimethylated, dimethylated and monomethylated H3 Lys-4. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.