Thermo Fisher Scientific KDM5B Monoclonal Antibody (7H3D7)
KDM5B 단백질을 인식하는 마우스 단클론 항체로, Western blot, Flow cytometry, ELISA에 적합합니다. 인간 시료에 반응하며 비결합형 액상 형태로 제공됩니다. 단백질 G로 정제되어 높은 특이성과 재현성을 보장합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Flow Cytometry (Flow) | 1:200–1:400 | - |
| ELISA | 1:10,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7H3D7 |
| Immunogen | Purified recombinant fragment of human KDM5B (AA: 231–319) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787408 |
Product Specific Information
MA5-31785 has been tested in indirect ELISA.
Target Information
KDM5B is a histone demethylase that demethylates Lys-4 of histone H3, thereby playing a central role in the histone code. It does not demethylate histone H3 Lys-9 or H3 Lys-27. KDM5B demethylates trimethylated, dimethylated, and monomethylated H3 Lys-4. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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