Thermo Fisher Scientific EDG3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested dilution: 1:500–1:3,000
• View 1 publication

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, Jurkat, Raji
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

EDG-3 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-3 is sphingosine-1-phosphate. There are eight known members of the EDG receptor family, which are implicated in growth-related effects such as induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis. They also mediate cellular effector functions dependent on cytoskeletal responses such as contraction, secretion, adhesion, and chemotaxis. EDG receptors are developmentally regulated, differ in tissue distribution, and couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C, and several protein tyrosine kinases. EDG-3 is expressed in cardiovascular, leukocyte-containing, and other tissues.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.