Thermo Fisher Scientific SFRS15 Polyclonal Antibody
Thermo Fisher Scientific의 SFRS15 폴리클로날 항체는 인간 SFRS15 단백질을 인식하며, WB, IHC(P), ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 높은 특이성과 재현성을 제공합니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SFRS15. Recombinant protein control fragment (Product #RP-91820). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647188 |
Product Specific Information
Immunogen sequence:
MHHQVPLPPN GQMPGFGLLP TPPFPPMAQP VIPPTPPVQQ PFQASFQAQN EPLTQKPHQQ EMEVEQPCIQ EVKRHMSDNR KSRSRSASRS PK
Highest antigen sequence identity to the following orthologs:
- Mouse: 57%
- Rat: 56%
Target Information
The family of SR factors all contain one or more RNA recognition motifs (RRM) and an SR-rich domain. They are essential for constitutive splicing and regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites.
Splicing factor arginine/serine-rich 15 (SFRS15), also designated CTD-binding SR-like protein RA4, contains one RRM and one SR-rich domain. SFRS15 interacts with the C-terminal repetitive domain (CTD) of Pol II and is believed to functionally and physically link transcription and pre-mRNA processing.
Localized to the nucleus, SFRS15 is expressed as two isoforms produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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