Thermo Fisher Scientific HACE1 Polyclonal Antibody
HACE1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 반응성 검증됨. WB, IHC, ELISA 등 다양한 응용 가능. Affinity chromatography로 정제된 고품질 항체로, 연구용으로만 사용.
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Thermo Fisher Scientific HACE1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (aa 1–100 of human HACE1, NP_0658222) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.65 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901789 |
Product Specific Information
- Positive Samples: 293T, HeLa, Mouse brain, Mouse lung, Mouse spleen, Mouse testis
- Immunogen sequence:
MERAMEQLNR LTRSLRRART VELPEDNETA VYTLMPMVMA DQHRSVSELL SNSKFDVNYA FGRVKRSLLH IAANCGSVEC LVLLLKKGAN PNYQDISGCT
Target Information
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, serving as a signal for Golgi reassembly after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and degradation of active RAC1, playing a role in host defense against pathogens. May also act as a transcription regulator via interaction with RARB.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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