Thermo Fisher Scientific NUP160 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Samples: HeLa, A-431, Jurkat, HepG2
• Immunogen sequence:
  ALERSFVELS GAERERPRHF REFTVCSIGT ANAVAGAVKY SESAGGFYYV ESGKLFSVTR NRFIHWKTSG DTLELMEESL DINLLNNAIR LKFQNCSVLP GGVYVSETQN R

Target Information

The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm. The mammalian nucleoporin (NUP)-160 is part of the hetero-oligomeric complex that also contains NUP107, NUP133, NUP96, and the mammalian homolog of yeast sec13p.
While the majority of the NUP107–160 nuclear pore sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and pro-metaphase spindle poles in mitotic cells, in association with proteins such as Mad1, Mad2, Bub3, and Cdc20.
Immunodepletion of the NUP107–160 complex results in defective spindle assembly, indicating multiple functions. NUP160 has also been identified as an HIV dependency factor (HDF), suggesting its potential as a drug target in HIV treatment. Multiple isoforms of NUP160 are known to exist.

주의사항

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.