Thermo Fisher Scientific Activin A Recombinant Rabbit Monoclonal Antibody (21H15L7)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 2 µg/mL

Product Specifications

Product Specific Information

• Predicted to react with Monkey, Bovine, Sheep, and Goat.
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning antibody DNA sequences from immunoreactive rabbits.
• Advantages include:
  • Better specificity and sensitivity
  • Lot-to-lot consistency
  • Animal origin-free formulations
  • Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

Target Information

Activins are dimeric growth and differentiation factors belonging to the transforming growth factor-beta (TGF-beta) superfamily.
They signal through a heteromeric complex of receptor serine kinases, including type I (I and IB) and type II (II and IIB) receptors.
These receptors are transmembrane proteins composed of:

• Ligand-binding extracellular domain with cysteine-rich region
• Transmembrane domain
• Cytoplasmic domain with serine/threonine specificity

Type I receptors are essential for signaling, while type II receptors are required for ligand binding and type I receptor expression.
Upon ligand binding, type I and II receptors form a stable complex, leading to phosphorylation of type I receptors by type II receptors.
Mutations in Activin A are associated with fibrodysplasia ossificans progressiva.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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