Thermo Fisher Scientific ARTS Polyclonal Antibody
Rabbit polyclonal antibody recognizing human ARTS protein. Validated for WB and IHC(P) at 2 µg/mL. Useful for apoptosis and TGF-β signaling research. Supplied as liquid at 1 mg/mL, store at 4°C short-term or -20°C long-term.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide KRFLEDTTDDGE, corresponding to amino acids 3–14 of Human ARTS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2187162 |
Product Specific Information
- Recommended positive controls: Human lung, kidney, and spleen tissue lysates
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
Target Information
Apoptosis is related to many diseases and developmental processes. Mitochondrial proteins such as cytochrome c, Apaf-1, and AIF play important roles in apoptosis.
A novel mitochondrial septin-like protein, designated ARTS (Apoptosis Related Protein in TGF-beta Signaling Pathway), has been identified.
ARTS is encoded by the human septin H5/PNUTL2/CDCrel2b gene, localized to mitochondria, and translocates to the nucleus during apoptosis.
It is expressed in many tissues and enhances cell death induced by TGF-beta and, to a lesser extent, by other apoptotic agents such as TNF-α and Fas ligand.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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