ELK Biotechnology LAT (phospho-Tyr171) rabbit pAb
T세포 활성화 관련 LAT 단백질의 Tyr171 인산화 형태를 인식하는 rabbit polyclonal antibody. WB 및 IHC에 적합하며, 세포막에 존재하는 신호전달 단백질 분석에 유용. 고순도 IgG, -20°C에서 1년 안정 보관.
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제품명
LAT (phospho-Tyr171) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Linker for activation of T-cells family member 1 (36 kDa phospho-tyrosine adapter protein) (pp36) (p36-38) |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized phospho peptide around human LAT (Tyr171) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 34 kD |
| Gene ID (Human) | 27040 |
| Human Swiss-Prot No. | O43561 |
| Cellular Localization | Cell membrane; Single-pass type III membrane protein; Present in lipid rafts |
| Species Reactivity | Human; Rat; Mouse |
Background
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, it recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.
[Provided by RefSeq, Jul 2008]
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