ELK Biotechnology PCDGE rabbit pAb
PCDGE 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 IHC에 적합합니다. 인간, 랫드, 마우스 시료에 반응하며, 세포막 단백질 분석에 활용됩니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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ELK Biotechnology PCDGE rabbit pAb
제품 개요
PCDGE rabbit pAb는 인간 PCDGE 단백질(AA 150-200) 유래 합성 펩타이드를 면역원으로 제작된 토끼 폴리클로날 항체입니다. 세포막 단백질 분석 및 신경세포 간 접착 관련 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | PCDGE rabbit pAb |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human PCDGE (AA range: 150–200) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 56103 |
| Human Swiss-Prot No. | Q9Y5G2 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression.
The gamma gene cluster includes 22 genes divided into 3 subfamilies: Subfamily A (12 genes), Subfamily B (7 genes and 2 pseudogenes), and Subfamily C (3 genes). The tandem array of 22 large variable region exons is followed by a constant region containing 3 exons shared by all genes in the cluster.
Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
[provided by RefSeq, Jul 2008]
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