ELK Biotechnology MBD2 rabbit pAb
MBD2 단백질을 인식하는 토끼 다클론 항체로 WB, ELISA, IHC에 적합합니다. 인간 및 생쥐 시료에 반응하며, 핵 내 메틸화 DNA 결합 단백질 연구에 활용됩니다. 고순도 IgG 형태로 -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology MBD2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | MBD2 rabbit pAb |
| Applications | WB, ELISA, IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | Synthesized peptide derived from human MBD2 (AA range: 110–160) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 8932 |
| Human Swiss-Prot No. | Q9UBB5 |
| Cellular Localization | Nucleus; localized in discrete nuclear foci. Detected at replication foci in late S phase. |
| Species Reactivity | Human, Mouse |
Background
DNA methylation is a major epigenetic modification in eukaryotic genomes, essential for mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 form a family of nuclear proteins characterized by a methyl-CpG binding domain (MBD). Except for MBD3, these proteins specifically bind to methylated DNA. MECP2, MBD1, and MBD2 can repress transcription from methylated promoters. The MBD2 protein may mediate biological consequences of methylation and is also reported to function as a demethylase, activating transcription by reversing methylation-induced gene silencing. Two transcript variants encoding different isoforms have been identified for this gene (RefSeq, Feb 2011).
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