Thermo Fisher Scientific Macrophage and Histiocytoma Marker Monoclonal Antibody (D11)
인간 대식세포 및 조직구 표지용 단클론 항체(D11). IHC(P) 및 IHC(PFA) 실험에 적합. 인간 시료에 반응하며, 마우스·랫·돼지에는 비반응성. 세포막 및 리소좀 내 항원 검출에 유용. 연구용 한정 제품.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | D11 |
| Immunogen | Membrane preparation from human hepatocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse, Rat, or Pig.
Target Information
In Western blotting, this antibody detects an antigen of approximately 125 kDa in human liver and 135 kDa in tumors of histiocytic origin. Comparative studies with a standard CD68 monoclonal antibody indicate that their antigens are distinct. The antigen recognized by this antibody is located on the plasma membrane and within cytoplasmic structures, including lysosomes, across various macrophage types.
This monoclonal antibody shows restricted reactivity to cells of the monocyte/macrophage system. It specifically reacts with blood monocytes and stains resident macrophages in a wide variety of human tissues. It does not stain antigen-presenting cells such as Langerhans cells. Reportedly, its reactivity is restricted to histiocytes and macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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