Thermo Fisher Scientific GPLD1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.

Target Information

GPLD1 is expressed in numerous tissues and cells and specifically cleaves GPI-anchored proteins. The liver exhibits the highest level of GPI-PLD expression and is the primary organ contributing to serum GPLD1. GPLD1 associates with apolipoproteins AI and AIV in serum. Elevated serum GPLD1 levels are linked to insulin resistance and increased serum triglycerides. Many surface proteins are attached to eukaryotic cell membranes via glycosylphosphatidylinositol (GPI) anchors, which are covalently bound to the C-terminus of the protein. Cleavage of the GPI moiety by GPLD1—the only enzyme known to cleave the GPI anchor—may regulate the attachment of these proteins to the cell surface or facilitate their release into the extracellular environment.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.