Thermo Fisher Scientific FceR1 alpha Monoclonal Antibody (MAR-1), PE, eBioscience

Thermo Fisher Scientific FceR1 alpha Monoclonal Antibody (MAR-1), PE, eBioscience

Applications and Tested Dilution

Product Specifications

Additional Formats Available:

• Unconjugated
• APC
• APC-eFluor 780
• Biotin
• eFluor 450
• FITC
• Functional Grade
• PE-Cyanine7
• PE-eFluor 610
• PerCP-eFluor 710
• Super Bright 436
• Super Bright 600
• Request custom conjugation

Product Specific Information

The MAR-1 monoclonal antibody reacts with the Fc epsilon Receptor I alpha subunit, an IgE-binding subunit lacking signal-transducing ability. FcεRIα is expressed on mast and basophil cells and is up-regulated by the presence of IgE. It forms a tetrameric complex with one beta and two gamma subunits, which contain ITAM motifs. The FcεRI complex triggers IgE-mediated allergic reactions.

Applications Reported: Flow cytometric analysis
Applications Tested: Tested by flow cytometric analysis of the MC/9 mouse mast cell line. Use ≤0.06 µg/test (100 µL final volume). Optimize antibody titration per assay.
Excitation: 488–561 nm
Emission: 578 nm
Laser: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered

Target Information

FceR1 (Fc epsilonR1 alpha) is a subunit of the high-affinity IgE receptor. It forms a tetrameric complex (α, β, and two γ subunits). The α subunit binds IgE, while β and γ subunits enable signal transduction. This receptor initiates allergic responses by coupling allergen-bound IgE with mast cells, leading to histamine release and synthesis of prostaglandins and leukotrienes—key mediators of hypersensitivity reactions such as hay fever and asthma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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